STRUCTURE OF THE DECODING CENTER OF THE RIBOSOME

The decoding center of the ribosome provides mRNA translation and the fidelity of the codon-anticodon interactions along with mRNA transloca tion in the course of protein biosynthesis. The three-dimensional stru cture of the ribosome decoding center is still unknown. However, up to now a number of direct and indirect experimental data on the structur al and functional organization of the decoding center have been obtain ed. In this paper the main components of the decoding center are descr ibed on the basis of our own experimental results combined with data f rom the literature. A model of their spatial arrangement at the small ribosomal subunit is suggested.