AMELIORATION OF FLU-LIKE SYMPTOMS AT THE ONSET OF INTERFERON BETA-1B THERAPY IN MULTIPLE-SCLEROSIS BY LOW-DOSE ORAL STEROIDS IS RELATED TO A DECREASE IN INTERLEUKIN-6 INDUCTION

Authors
MARTINEZCACERES EM RIO J BARRAU M DURAN I BORRAS C TINTORE M MONTALBAN X
Citation
Em. Martinezcaceres et al., AMELIORATION OF FLU-LIKE SYMPTOMS AT THE ONSET OF INTERFERON BETA-1B THERAPY IN MULTIPLE-SCLEROSIS BY LOW-DOSE ORAL STEROIDS IS RELATED TO A DECREASE IN INTERLEUKIN-6 INDUCTION, Annals of neurology, 44(4), 1998, pp. 682-685
Citations number
19
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
44
Issue
4
Year of publication
1998
Pages
682 - 685
Database
ISI
SICI code
0364-5134(1998)44:4<682:AOFSAT>2.0.ZU;2-P
Abstract
Low-dose oral steroid use at the onset of interferon beta-1b (IFN beta -1b) therapy in relapsing-remitting multiple sclerosis (RR-MS) patient s reduces flulike symptoms. To determine the mechanism by which steroi d treatment minimizes these side effects, we analyzed the percentage o f interleukin-6 (IL-6)-, interferon-gamma (IFN-gamma)-, tumor necrosis factor alpha (TNF-alpha)-, and IL-10-producing cells before and after 3 months of IFN beta-1b therapy onset. Our results support a relation ship between IL-6 induction and fever, Such side effects can be amelio rated bg steroids.