PRESENCE OF 4-HYDROXYNONENAL IN CEREBROSPINAL-FLUID OF PATIENTS WITH SPORADIC AMYOTROPHIC-LATERAL-SCLEROSIS

A marker of lipid peroxidation 4-hydroxynonenal (HNE) was elevated in the cerebrospinal fluid (CSF) of a patient with sporadic amyotrophic l ateral sclerosis (sALS) compared with that of most patients with other neurological diseases. Such elevations of HNE were sufficient to kill cyclic adenosine monophosphate (cAMP)-differentiated motor neuron hyb rid cells in vitro, and anti-oxidants prevented this HNE-dependent cel l death. These data suggest that oxidative stress and lipid peroxidati on are associated with and may promote motor neuron degeneration in sA LS.