INFLUENCE OF THE MEXAB-OPRM MULTIDRUG EFFLUX SYSTEM ON QUORUM SENSINGIN PSEUDOMONAS-AERUGINOSA

Authors
EVANS K PASSADOR L SRIKUMAR R TSANG E NEZEZON J POOLE K
Citation
K. Evans et al., INFLUENCE OF THE MEXAB-OPRM MULTIDRUG EFFLUX SYSTEM ON QUORUM SENSINGIN PSEUDOMONAS-AERUGINOSA, Journal of bacteriology (Print), 180(20), 1998, pp. 5443-5447
Citations number
44
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology (Print) → ACNP
ISSN journal
00219193
Volume
180
Issue
20
Year of publication
1998
Pages
5443 - 5447
Database
ISI
SICI code
0021-9193(1998)180:20<5443:IOTMME>2.0.ZU;2-4
Abstract
Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellula r virulence factors known to be regulated by quorum sensing. Such muta nts also produce less acylated homoserine lactone autoinducer PAI-I, c onsistent with an observed reduction in lasI expression. These data su ggest that PAI-1 is a substrate for MexAB-OprM, and its resulting excl usion from cells hyperexpressing MexAB-OprM limits PAI-l-dependent act ivation of lasI and the virulence genes.