M. Lasperas et al., CHIRAL MESOPOROUS TEMPLATED SILICAS AS HETEROGENEOUS INORGANIC-ORGANIC CATALYSTS IN THE ENANTIOSELECTIVE ALKYLATION OF BENZALDEHYDE, Tetrahedron : asymmetry, 9(17), 1998, pp. 3053-3064
New mesoporous templated silicas of the MCM-41 family covalently linke
d to chiral ephedrine are used as heterogeneous chiral auxiliaries in
the enantioselective alkylation of benzaldehyde by diethylzinc. Promis
ing results are obtained with these inorganic-organic catalysts. Vario
us factors which may affect the activity, selectivity and enantioselec
tivity are studied. Comparison with homogeneous catalysis is carried o
ut. (C) 1998 Elsevier Science Ltd. All rights reserved.