Objective: Giant cell arteritis (GCA) often presents with devastating
visual loss in the elderly, yet early diagnosis and treatment can prev
ent visual loss. The authors report two cases of GCA in which scalp ne
crosis, a rare finding not reported previously in the ophthalmic liter
ature, played an important role in diagnosis. Design: Observational ca
se reports and literature review. Participants: Two patients with GCA
had scalp necrosis, Intervention: Intravenous steroid administration w
as performed. Main Outcome Measure: Vision and healing of scalp necros
is were measured. Results: One patient had scalp necrosis that was dia
gnosed incorrectly preceding visual loss. Another patient had visual l
oss in one eye diagnosed as nonarteritic anterior ischemic optic neuro
pathy, He had scalp necrosis develop 2 weeks later, leading to the cor
rect diagnosis of GCA, There are 21 previously reported cases of scalp
necrosis with GCA, none in the ophthalmic literature, most of which w
ere undiagnosed until the onset of visual loss. In addition, a higher
rate of visual loss is seen in GCA with scalp necrosis. Conclusions: S
calp necrosis is a valuable sign that frequently is misdiagnosed until
visual loss occurs, In addition, it may indicate a more severe vascul
itis, This finding should be added to the list of signs evaluated in p
atients for whom GCA is in the differential diagnosis.