GLANDULAR ODONTOGENIC CYST (SIALO-ODONTOGENIC CYST) - REPORT OF 2 CASES AND LITERATURE-REVIEW OF 45 PREVIOUSLY REPORTED CASES

The clinical, radiological, histopathological and immunohistochemical (cytokeratin) features of two cases of glandular odontogenic cyst (GOC ) are presented and discussed in a review of 45 cases of GOC hitherto reported. Of cases with available information, 34 occurred in the mand ible and 6 in the maxilla; the male:female ratio was 19:28, and the me an age was 46.7 years in males and 50.0 years in females. Six cysts re curred once after 2-8 years (mean 2 years 8 months) and 2 (5.3%) recur red twice after 2 and 5 years and after 3 and 5 years, respectively, g iving a rate of recurrence of 21%. The identification of osteodentin i n one of the present cases and the co-expression of cytokeratins (CK) 13, 19 and 8 strongly support the concept of odontogenic differentiati on in the GOC. Careful surgical removal of the lesion succeeded by a 5 -year follow-up period is recommended.