ANTIINFLAMMATORY EFFECTS OF MAO-BUSHI-SAISHIN-TO IN MICE AND RATS

Effects of Mao-Bushi-Saishin-to (MBS) on anti-inflammatory activities were examined in mice and rats. MBS significantly inhibited the increa se in vascular permeability induced by acetic acid, the ear edema indu ced by arachidonic acid and phorbol ester, and the cutaneous extravasa tion induced by bradykinin and histamine. MBS, however, was not effect ive against the serotonin-induced cutaneous permeability increase in m ice. MBS significantly inhibited carrageenin-induced hind foot edema a nd cotton pellet-induced granulation tissue growth in rats. These resu lts show that MBS may exert anti-inflammatory effects through the unde rlying mechanism(s) of preventing mediator release from mast cells and macrophages.