HLA AND HPA TYPING IN IDIOPATHIC THROMBOCYTOPENIC PURPURA PATIENTS TREATED WITH KAMI-KIHI-TO

We performed human leukocyte antigen (HLA) and human platelet antigen (HPA) in patients with Kami-kihi-to-responsive idiopathic thrombocytop enic purpura. The HLA-A2, A61 and Cw1 were significantly increased in responders compared with nonresponders, as were HLA DRB1 0901, DRB1 * 1502, and DPB1 0501. In contrast, HLA DPB1 *0201 and DPB1 *0901 were significantly decreased in responders. The a/b genotype of HPA-2 and a /a genotype of HPA-3 were markedly increased in nonresponders, and ant i-GPIb antibody was also increased. These results suggest that HLA, HP A, and anti-GP antibody studies may predict the response of idiopathic thrombocytopenic purpura to Kami-kihi-to.