BRASILICARDIN-A - A NOVEL TRICYCLIC METABOLITE WITH POTENT IMMUNOSUPPRESSIVE ACTIVITY FROM ACTINOMYCETE NOCARDIA-BRASILIENSIS

Authors
SHIGEMORI H KOMAKI H YAZAWA K MIKAMI Y NEMOTO A TANAKA Y SASAKI T IN Y ISHIDA T KOBAYASHI J
Citation
H. Shigemori et al., BRASILICARDIN-A - A NOVEL TRICYCLIC METABOLITE WITH POTENT IMMUNOSUPPRESSIVE ACTIVITY FROM ACTINOMYCETE NOCARDIA-BRASILIENSIS, Journal of organic chemistry, 63(20), 1998, pp. 6900-6904
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
63
Issue
20
Year of publication
1998
Pages
6900 - 6904
Database
ISI
SICI code
0022-3263(1998)63:20<6900:B-ANTM>2.0.ZU;2-Q
Abstract
A novel tricyclic metabolite, brasilicardin A (1), with potent immunos uppressive activity has been isolated from the cultured broth of the a ctinomycete Nocardia brasiliensis IFM 0406, and the structure includin g absolute stereochemistry was established on the basis of spectroscop ic data, chemical means, and X-ray analysis. Brasilicardin A (1) is th e first tricyclic compound consisting of an anti/syn/anti-perhydrophen anthrene skeleton with a rhamnose, an N-acetylglucosamine, and an amin o acid moiety.