A HIGHLY CYTOTOXIC L-RHAMNOSE ANALOG OF THE ANTITUMOR AGENT SPICAMYCIN

Authors
MARTIN A BUTTERS TD FLEET GWJ
Citation
A. Martin et al., A HIGHLY CYTOTOXIC L-RHAMNOSE ANALOG OF THE ANTITUMOR AGENT SPICAMYCIN, Chemical communications, (19), 1998, pp. 2119-2120
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
19
Year of publication
1998
Pages
2119 - 2120
Database
ISI
SICI code
1359-7345(1998):19<2119:AHCLAO>2.0.ZU;2-O
Abstract
Rhamnospicamycin 2, a rhamnose analogue (containing adenine, a carbohy drate, an amino acid and a fatty acid) of the naturally occurring comb inatorial library spicamycin 1, is prepared from L-rhamnose and shown to be highly cytotoxic towards human myeloma cells (IC50 = 120 nM).