ENANTIOSELECTIVE SYNTHESIS OF AN AXIALLY CHIRAL 1,7-NAPHTHYRIDINE-6-CARBOXAMIDE DERIVATIVE HAVING POTENT ANTAGONIST ACTIVITY AT THE NK1 RECEPTOR

Authors
IKEURA Y ISHIMARU T DOI T KAWADA M FUJISHIMA A NATSUGARI H
Citation
Y. Ikeura et al., ENANTIOSELECTIVE SYNTHESIS OF AN AXIALLY CHIRAL 1,7-NAPHTHYRIDINE-6-CARBOXAMIDE DERIVATIVE HAVING POTENT ANTAGONIST ACTIVITY AT THE NK1 RECEPTOR, Chemical communications, (19), 1998, pp. 2141-2142
Citations number
15
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
19
Year of publication
1998
Pages
2141 - 2142
Database
ISI
SICI code
1359-7345(1998):19<2141:ESOAAC>2.0.ZU;2-6
Abstract
A new and highly potent NK1 antagonist, (aR,9R)-3 oromethyl)benzyl]-8, 9,10,11-tetrahydro-9-methyl-5- (4-methylphenyl)-7H-[ 1,4]diazocino[2,1 g][1,7]naphthyridine-6,13-dione], was atropdiastereoselectively synthe sized in good yield by cyclization of the chiral intermediate 6b.