AGE-RELATED-CHANGES OF MESSENGER-RNA EXPRESSION OF AMYLOID PRECURSOR PROTEIN IN THE BRAIN OF SENESCENCE-ACCELERATED MOUSE

Authors
CHO HS KIM SS CHOI W KIM SH JEONG SJ HONG R CHONG YH LEE YJ PARK CW LEE KW SUH YH
Citation
Hs. Cho et al., AGE-RELATED-CHANGES OF MESSENGER-RNA EXPRESSION OF AMYLOID PRECURSOR PROTEIN IN THE BRAIN OF SENESCENCE-ACCELERATED MOUSE, Comparative biochemistry and physiology. B. Comparative biochemistry, 112(2), 1995, pp. 399-404
Citations number
34
Categorie Soggetti
Biology
Journal title
Comparative biochemistry and physiology. B. Comparative biochemistry → ACNP
ISSN journal
03050491
Volume
112
Issue
2
Year of publication
1995
Pages
399 - 404
Database
ISI
SICI code
0305-0491(1995)112:2<399:AOMEOA>2.0.ZU;2-3
Abstract
APP695 mRNA is only expressed in the brains of SAM. The expression of APP mRNA in SAM P1 mice brains is more marked than that in SAM R1 mice brain. APP mRNA expression was increased with advancing age in all br ain regions of SAM P1 mice compared with SAM R1, Especially, the chang es of the amount of APP mRNA in the prosencephalon and the mesencephal on are significant at P value of 0.05. We suggest that overexpression of APP mRNA may be related to accelerated aging phenomenon in the SAM brain. This is the first report of age-related increase in the amount of APP mRNA in the SAM brain.