SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF FUROXAN DERIVATIVES DESIGNED AS NOVEL FUNGICIDE

Furoxan derivatives 3-11 were designed and synthesized as potential fu ngicides. Symmetrically substituted furoxan derivatives 3a-j were prep ared by dimerization of the corresponding nitrile oxide generated from N-hydroxyliminoyl chloride 2 in situ. Further functional group modifi cations of aldehyde 4, a key intermediate, generated furoxan derivativ es 5-11. The fungicidal activities of furoxan derivatives 3-11 were ob served over a broad spectrum of plant fungi at 250 ppm.