EVALUATION OF THE CYTOTOXIC ACTIVITY OF CHIRAL (E)-13-HYDROXY-10-OXO-11-OCTADECENOIC ACID AND ITS LACTONE

Authors
HAYASHI Y NISHIKAWA Y MORI H MATSUSHITA Y SUGAMOTO K MATSUI T
Citation
Y. Hayashi et al., EVALUATION OF THE CYTOTOXIC ACTIVITY OF CHIRAL (E)-13-HYDROXY-10-OXO-11-OCTADECENOIC ACID AND ITS LACTONE, Bioscience, biotechnology, and biochemistry, 62(9), 1998, pp. 1771-1773
Citations number
9
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
62
Issue
9
Year of publication
1998
Pages
1771 - 1773
Database
ISI
SICI code
0916-8451(1998)62:9<1771:EOTCAO>2.0.ZU;2-#
Abstract
Both the S and R enantiomers of (E)-13-hydroxy-10-oxo-11-octadecenoic acid (1) and (E)-10-oxo-11-octadecen-13-olide (2) had similar IC50 val ues against P388 mouse leukemia cells; i.e. the stereochemistry of the asymmetric center of 1 and 2 had no influence on the cytotoxic activi ty. Bioassay results of various compounds related to 1 and 2 suggests that the 10-oxo and lactone moieties of 2 were important for enhancing the cytotoxicity.