EFFECTS OF BETA-LACTOGLOBULIN ON THE TIGHT-JUNCTIONAL STABILITY OF CACO-2-SF MONOLAYER

Authors
HASHIMOTO K NAKAYAMA T SHIMIZU M
Citation
K. Hashimoto et al., EFFECTS OF BETA-LACTOGLOBULIN ON THE TIGHT-JUNCTIONAL STABILITY OF CACO-2-SF MONOLAYER, Bioscience, biotechnology, and biochemistry, 62(9), 1998, pp. 1819-1821
Citations number
13
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
62
Issue
9
Year of publication
1998
Pages
1819 - 1821
Database
ISI
SICI code
0916-8451(1998)62:9<1819:EOBOTT>2.0.ZU;2-U
Abstract
The mechanisms for tight-junction (TJ) stabilization by beta-lactoglob ulin (beta-Lg) were studied. Treatment of Caco-2-SF cells with inhibit ors for some enzymes in the intracellular signal transduction pathways and a cytoskeleton-disturbing agent (cytochalasin D) reduced the TJ-s tabilizing activity of beta-Lg. So beta-Lg is suggested to modulate th e cytoskeletal structure through the activation of phospholipase C and protein kinase C, resulting in the TJ stabilization.