EFFECTS OF RINGER LACTATE, MEDROXYPROGESTERONE ACETATE, GONADOTROPIN-RELEASING-HORMONE ANALOG AND ITS DILUENT ON THE PREVENTION OF POSTSURGICAL ADHESION FORMATION IN RAT MODELS
C. Ustun et al., EFFECTS OF RINGER LACTATE, MEDROXYPROGESTERONE ACETATE, GONADOTROPIN-RELEASING-HORMONE ANALOG AND ITS DILUENT ON THE PREVENTION OF POSTSURGICAL ADHESION FORMATION IN RAT MODELS, Gynecologic and obstetric investigation, 46(3), 1998, pp. 202-205
Fifty adult female rats were randomly divided into five groups. Before
the standard surgical procedure which consisted of creating a lesion
with electrocautery over the uterus, leuprolide acetate (LA) together
with its diluent, the diluent alone and medroxyprogesterone acetate (M
PA) were injected to the third, fourth, and fifth groups, respectively
. Ringer's lactate (RL) solution was applied intraperitoneally to the
second group at the end of the surgery. Group I received no medication
. Relaparotomy was performed 3 weeks later to evaluate the adhesions.
The mean adhesion scores were (mean +/- SD) 2.6 +/- 0.7, 1.4 +/- 0.8,
0.9 +/- 0.6, 2.3 +/- 0.8, and 0.8 +/- 0.6 in groups I, II, III, IV, an
d V, respectively. The postsurgical adhesions were significantly less
in the groups treated with RL, LA, and MPA.