CASSETTE DOSING - RAPID IN-VIVO ASSESSMENT OF PHARMACOKINETICS

Cassette dosing, combining many test chemicals into one dose solution, is an attractive method for increasing the throughput of in vivo phar macokinetic experiments. This dosing technique depends on the sensitiv ity and selectivity of modern analytical techniques, particularly HPLC /MS/MS. Cassettes vary in size, but even relatively small ones greatly increase the numbers of compounds investigated by reducing the effort devoted to animal handling, sample processing and sample analysis. Th e major drawback of cassette dosing is the potential for drug-drug int eractions.