MAGNETIC-RESONANCE-IMAGING OF CONTROLLED-RELEASE PHARMACEUTICAL DOSAGE FORMS

Magnetic resonance imaging offers us a powerful non-invasive method fo r picturing events inside controlled-release dosage Forms. It allows u s to observe, follow and measure important processes, such as hydratio n and diffusion, that can contribute directly to the process of drug r elease. The potential of this technique For increasing our understandi ng of drug release mechanisms, and the behaviour of dosage forms in vi tro and in vivo is only beginning to be exploited. The unique informat ion obtained from MRI studies will provide important detailed knowledg e in problem solving and formulation development.