THE SYNTHESIS OF A GAMMA-KETO-ALPHA-AMINO ACID, A KEY INTERMEDIATE INTHE SYNTHESIS OF MONATIN, A NEW NATURAL SWEETENER

Authors
HOLZAPFEL CW OLIVIER J
Citation
Cw. Holzapfel et J. Olivier, THE SYNTHESIS OF A GAMMA-KETO-ALPHA-AMINO ACID, A KEY INTERMEDIATE INTHE SYNTHESIS OF MONATIN, A NEW NATURAL SWEETENER, Synthetic communications, 23(18), 1993, pp. 2511-2526
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
23
Issue
18
Year of publication
1993
Pages
2511 - 2526
Database
ISI
SICI code
0039-7911(1993)23:18<2511:TSOAGA>2.0.ZU;2-O
Abstract
An efficient method was developed for the synthesis of the ketoamino a cid 2, a key intermediate in the synthesis of the novel sweet compound , monatin 1. Preparation of 2 entails coupling of a suitably protected indole acetate anion to an aspartic acid derivative.