Sg. Kitchen et al., COSTIMULATION OF NAIVE CD8(-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION()LYMPHOCYTES INDUCES CD4 EXPRESSION AND ALLOWS HUMAN), Journal of virology (Print), 72(11), 1998, pp. 9054-9060
Human immunodeficiency virus type 1 (HIV-1) infection requires cell su
rface expression of CD 1. Costimulation of CD8(+)/CD4(-) T lymphocytes
by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells
induced expression of CD4 and rendered these CD8 cells susceptible to
HIV-1 infection. Naive CD45RA(+) cells responded with greater express
ion of CD4 than did CD45RO(+) cells. CD8(+) lymphocytes derived from f
etal or newborn sources exhibited a greater tendency to express CD4, c
onsistent with their naive states. This mechanism of infection suggest
s HIV-induced perturbation of the CD8 arm of the immune response and c
ould explain the generally rapid disease progression seen in HIV-infec
ted children.