USE OF CORECEPTORS OTHER THAN CCR5 BY NON-SYNCYTIUM-INDUCING ADULT AND PEDIATRIC ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IS RARE IN-VITRO

We have tested a panel of pediatric and adult human immunodeficiency v irus type 1 (HIV-1) primary isolates for the ability to employ the fol lowing proteins as coreceptors during viral entry: CCRI, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1 V28, US28, and APJ. Most non -syncytium-inducing isolates could utilize only CCR5. All syncytium-in ducing viruses used CXCR4, some also employed V28, and one (DH123) use d CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isola tes from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal isolates, which were syncytium inducing , also used CXCR4, CCR8, V28, and APJ.