CD4(-LYMPHOCYTE DEPLETION IN HUMAN LYMPHOID-TISSUE EX-VIVO IS NOT INDUCED BY NONINFECTIOUS HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS() T)

We tested infectious human immunodeficiency virus type 1 (HIV-I), noni nfectious but conformationally authentic inactivated whole HIV-I virio ns, and purified gp120 for the ability to induce depletion of CD4(+) T cells in human lymphoid tissues ex vivo, Infectious CXCR4-tropic HIV- 1, but not matched inactivated virions or gp120, mediated CD4(+) T-cel l depletion, consistent with mechanisms requiring productive infection .