SHORT CONSENSUS REPEAT DOMAIN-1 OF DECAY-ACCELERATING FACTOR IS REQUIRED FOR ENTEROVIRUS-70 BINDING

Authors
KARNAUCHOW TM DAWE S LUBLIN DM DIMOCK K
Citation
Tm. Karnauchow et al., SHORT CONSENSUS REPEAT DOMAIN-1 OF DECAY-ACCELERATING FACTOR IS REQUIRED FOR ENTEROVIRUS-70 BINDING, Journal of virology (Print), 72(11), 1998, pp. 9380-9383
Citations number
36
Categorie Soggetti
Virology
Journal title
Journal of virology (Print) → ACNP
ISSN journal
0022538X
Volume
72
Issue
11
Year of publication
1998
Pages
9380 - 9383
Database
ISI
SICI code
0022-538X(1998)72:11<9380:SCRDOD>2.0.ZU;2-F
Abstract
Enterovirus 70 (EV70), like several other human enteroviruses, can uti lize decay-accelerating factor (DAF [CD55]) as an attachment protein, Using chimeric molecules composed of different combinations of the sho rt consensus repeat domains (SCRs) of DAF and membrane cofactor protei n (CD46), we show that sequences in SCRI of DAF are essential for EV70 binding. Of the human enteroviruses that can bind to DAF, only EV70 a nd coxsackievirus A21 require sequences in SCR1 for this interaction.