GLYCALS IN ENANTIOSPECIFIC SYNTHESIS

The review considers reactions of 1,2-unsaturated sugars or glycals, a s applied to the problems of enantiospecific synthesis of natural comp ounds, their molecules' fragments and analogues. The reactions retaini ng a heterocycle unchanged and those resulting in open-chained chiral units are discussed. The glycals are shown to be promising as starting chiral species. That contribute much to the configuration of asymetri c centres in the final products of multistep syntheses. Detailed exami nation is made for the reaction schemes that take place during synthet ic preparation natural compounds of various structures, such as O- and C-glycosides, nucleosides, oligosaccharides, pheromones, antibiotics, toxins, glycosphingolipids etc. Bibliography - 161 references.