Purpose: Recommendations for circumcision have significantly altered i
n the last several years. Studies have objectively established an incr
eased risk of urinary tract infection in uncircumcised boys. We evalua
ted the relationship between epididymitis and circumcision status. Mat
erials and Methods: We studied the relationships among the circumcisio
n status of 36 consecutive boys with epididymitis in a review of 128 w
ith acute scrotal inflammation (group 1), circumcision status of 43 in
whom the diagnosis of epididymitis at discharge home had been made el
sewhere (group 2), New York State hospital discharge figures for circu
mcision in newborns (group 3) and the regional prevalence of circumcis
ion in 200 consecutive pediatric emergency department patients at the
same institution with nonurological diagnoses (group 4). Results: New
York State Department figures indicate that 70% of male newborns are d
ischarged home with a hospital code for circumcision. Similarly an eva
luation of 200 consecutive male patients without urological diagnoses
younger than 18 years in the emergency department revealed that 131 (6
5%) were circumcised. Comparatively in groups 1 and 2 only 25 and 26%
of patients, respectively, were circumcised. The statistical differenc
e in circumcision status among the 4 groups was significant (p > 0.000
4). Conclusions: These data demonstrate with highly statistical signif
icance that a relationship exists between epididymitis and the presenc
e of a foreskin. We found that an intact foreskin is an important etio
logical factor in boys with epididymitis.