S. Dexeus et Pn. Barri, HYPERPROLACTINEMIA - AN INDUCTOR OF NEOPLASTIC CHANGES IN ENDOMETRIUM- A REPORT OF 2 CASES, Gynecological endocrinology, 12(4), 1998, pp. 273-275
Estrogen-dependent endometrial carcinomas habitually arise through a p
recursor lesion such as endometrial hyperplasia. The hormonal environm
ent of these patients remains unclear. Two cases of neoplastic changes
in the endometrium of patients with a chronic hyperprolactinemia are
presented. Despite the treatment with bromocriptine both patients deve
loped endometrial adenocarcinomas. Possible mechanisms involved in the
pathogenesis of these tumors are discussed.