R. Hamilton et C. Claoue, TOPICAL ANESTHESIA - PROXYMETACAINE VERSUS AMETHOCAINE FOR CLEAR CORNEAL PHACOEMULSIFICATION, Journal of cataract and refractive surgery, 24(10), 1998, pp. 1382-1384
Purpose: To evaluate the use of proparacaine (Proxymetacaine(R)) versu
s tetracaine (Amethocaine(R)) as the topical anesthetic agent or phaco
emulsification cataract surgery using a 3.5 mm clear corneal sutureles
s incision. Setting: Harold Hood Hospital, Romford, Essex, United King
dom. Methods: This prospective study comprised 40 randomly selected pa
tients. Twenty were given Proxymetacaine and 20, Amethocaine. The leve
l of discomfort experienced during delivery of the topical anesthetic
agent and during and immediately after surgery was measured using a pa
in score. During surgery topical anesthesia was supplemented by intrac
ameral lignocaine 1%. Results: Patients given Proxymetacaine experienc
ed no stinging sensation during its administration; those given Ametho
caine reported varying degrees of discomfort. The difference between g
roups was statistically significant (P < .01). There was no difference
between groups in the amount of discomfort experienced intraoperative
ly or postoperatively. Conclusion: Proxymetacaine is the topical analg
esic of choice for phacoemulsification because it produced no discomfo
rt on administration yet had the same analgesic properties as Amethoca
ine.