LAMOTRIGINE-ASSOCIATED ANTICONVULSANT HYPERSENSITIVITY SYNDROME

We systematically reviewed and analyzed published and unpublished case s of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to ide ntify characteristics of the syndrome. We identified 26 cases (mean ag e, 28 +/- 18 years; range, 3.5 to 74 years; 54% female), of which nine were published. The characteristics of the syndrome associated with l amotrigine are comparable to AHS induced by older aromatic anticonvuls ants.