ANTIMALARIAL ACTIVITY OF KALIHINOL-A AND NEW RELATIVE DITERPENOIDS FROM THE OKINAWAN SPONGE, ACANTHELLA SP

Authors
MIYAOKA H SHIMOMURA M KIMURA H YAMADA Y KIM HS WATAYA Y
Citation
H. Miyaoka et al., ANTIMALARIAL ACTIVITY OF KALIHINOL-A AND NEW RELATIVE DITERPENOIDS FROM THE OKINAWAN SPONGE, ACANTHELLA SP, Tetrahedron, 54(44), 1998, pp. 13467-13474
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
44
Year of publication
1998
Pages
13467 - 13474
Database
ISI
SICI code
0040-4020(1998)54:44<13467:AAOKAN>2.0.ZU;2-L
Abstract
Three new kalihinane diterpenoids Delta(9)-kalihinoi Y (1), 10-epikali hinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpeno ids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from t he Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity. (C) 1998 Elsevier Science Ltd. All rights reserved.