4 NEW MICROGININS, LINEAR PEPTIDES FROM THE CYANOBACTERIUM MICROCYSTIS-AERUGINOSA

Authors
ISHIDA K MATSUDA H MURAKAMI M
Citation
K. Ishida et al., 4 NEW MICROGININS, LINEAR PEPTIDES FROM THE CYANOBACTERIUM MICROCYSTIS-AERUGINOSA, Tetrahedron, 54(44), 1998, pp. 13475-13484
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
44
Year of publication
1998
Pages
13475 - 13484
Database
ISI
SICI code
0040-4020(1998)54:44<13475:4NMLPF>2.0.ZU;2-W
Abstract
Four new linear peptides, related to microginins 299-A (1) and 299-B ( 2), were isolated from the cyanobacterium Microcystis aeruginosa. Micr oginins 299-C (3) and 299-D (4), from M. aeruginosa (NIES-299), inhibi ted leucine aminopeptidase with IC50's of 2.0 and 6.4 mu g/mL, respect ively. Microginins 99-A (5) and 99-B (6), from M. aeruginosa (NIES-99) , did not inhibit leucine aminopeptidase. These structures were elucid ated to be 3-6 on the basis of 2D NMR data and chemical degradation. ( C) 1998 Elsevier Science Ltd. All rights reserved.