THE TOTAL SYNTHESIS OF (-PECTINATONE - AN ITERATIVE ALKYLATION APPROACH BASED ON THE SAMP-HYDRAZONE METHOD())

Authors
BIRKBECK AA ENDERS D
Citation
Aa. Birkbeck et D. Enders, THE TOTAL SYNTHESIS OF (-PECTINATONE - AN ITERATIVE ALKYLATION APPROACH BASED ON THE SAMP-HYDRAZONE METHOD()), Tetrahedron letters, 39(43), 1998, pp. 7823-7826
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
43
Year of publication
1998
Pages
7823 - 7826
Database
ISI
SICI code
0040-4039(1998)39:43<7823:TTSO(->2.0.ZU;2-K
Abstract
The marine natural product (+)-pectinatone containing 'skip' 1,3-dimet hyl stereocentres was synthesised via the iterative alkylation of prop anal SAMP-hydrazone with beta-branched iodides. Factors affecting the selectivity of the alkylation reaction and the in situ formation of vo latile beta-branched iodides are described. (C) 1998 Elsevier Science Ltd. All rights reserved.