BETA-TURN MODULATION BY THE CYCLOHEXANE ANALOGS OF PHENYLALANINE

Authors
JIMENEZ AI CATIVIELA C PARIS M PEREGRINA JM AVENOZA A AUBRY A MARRAUD M
Citation
Ai. Jimenez et al., BETA-TURN MODULATION BY THE CYCLOHEXANE ANALOGS OF PHENYLALANINE, Tetrahedron letters, 39(43), 1998, pp. 7841-7844
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
43
Year of publication
1998
Pages
7841 - 7844
Database
ISI
SICI code
0040-4039(1998)39:43<7841:BMBTCA>2.0.ZU;2-B
Abstract
X-ray diffraction experiments have evidenced that the orientation of t he aromatic side chain determine the folding tendencies of (BuCO)-Bu-t -Pro-c(6)Phe-(NHPr)-Pr-i, where c(6)Phe denotes the (S,S) and (R,R) cy clohexane analogues of phenylalanine. In the solid state, both dipepti des are beta-folded, the beta-turn type being dictated by the stereoch emistry of the cyclohexane ring. (C) 1998 Published by Elsevier Scienc e Ltd. All rights reserved.