MANGANESE CATALYZED ASYMMETRIC OXIDATION OF ALKANES TO OPTICALLY-ACTIVE KETONES BEARING ASYMMETRIC CENTER AT THE ALPHA-POSITION

Authors
KOMIYA N NOJI S MURAHASHI SI
Citation
N. Komiya et al., MANGANESE CATALYZED ASYMMETRIC OXIDATION OF ALKANES TO OPTICALLY-ACTIVE KETONES BEARING ASYMMETRIC CENTER AT THE ALPHA-POSITION, Tetrahedron letters, 39(43), 1998, pp. 7921-7924
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
43
Year of publication
1998
Pages
7921 - 7924
Database
ISI
SICI code
0040-4039(1998)39:43<7921:MCAOOA>2.0.ZU;2-2
Abstract
Chiral (salen)manganese(III) complex catalyzed oxidation of symmetrica l alkanes with iodosylbenzene gives the corresponding optically active ketones (up to 70% ee). The optically active 2-hydroxy-1-indanone (7) thus obtained is a versatile precursor of cis-l-amino-2-indanol (8) w hich is a key intermediate of chiral auxiliary and anti HIV protease i nhibitor (9). (C) 1998 Elsevier Science Ltd. All rights reserved.