RAISED FACTOR-VIII IS ASSOCIATED WITH CORONARY THROMBOTIC EVENTS

Coagulation is triggered during the onset of myocardial infarction, re sulting in vascular occlusion. However, a causal role for individual h aemostatic factors in the development of thrombotic occlusion is not e stablished. Three cases (all relatively young women) are reported of r aised factor VIII associated with myocardial infarction. Two patients presented acutely with myocardial infarction at a relatively young age with no preceding history of angina. The other patient had had venous thrombosis when young and activated protein C resistance (APCR), with out the presence of factor V Leiden. A functional relation exists betw een APCR and factor VIII; therefore, raised factor VIII may contribute to APCR and the increased thrombotic risk in patients without factor V Leiden. Factor VIII is an important risk factor for atherothrombotic events, including sudden death, in patients with vascular disease. Th ese cases support the association of raised factor VIII with acute thr ombotic events, even in patients without significant underlying athero matous disease.