M. Johnsen et al., CANCER INVASION AND TISSUE REMODELING - COMMON THEMES IN PROTEOLYTIC MATRIX DEGRADATION, Current opinion in cell biology, 10(5), 1998, pp. 667-671
Analysis of extracellular matrix degradation systems has led to the in
sight that in cancer invasion there is often crucial interplay between
cancer cells and several types of surrounding non-neoplastic stromal
cells, Likewise, in normal tissue remodeling processes, the synthesis
of proteolytic components is often distributed between several cell ty
pes, and there are strong similarities between neoplastic and nonneopl
astic processes in the same tissue. Thus, tissue remodeling events are
excellent models for studies of extracellular proteolysis in cancer.
This has become even clearer by recent analyses of genetically modifie
d mice.