TUMOR EXPRESSION OF FAS LIGAND (CD95L) AND THE CONSEQUENCES

Tumors of diverse origin have recently been shown to express CD95 liga nd and to induce apoptosis in CD95-expressing targets in vitro; howeve r, in vivo, enhanced tumor growth and rejection have both been observe d as a consequence of either immunosuppressive or proinflammatory func tions of CD95 ligand. The final in vivo outcome of CD95 ligand express ion will depend upon a complex balance of interactions relevant for ea ch tumor in its particular microenvironment.