HOW DO CYTOTOXIC LYMPHOCYTES KILL THEIR TARGETS

Authors
SHRESTA S PHAM CTN THOMAS DA GRAUBERT TA LEY TJ
Citation
S. Shresta et al., HOW DO CYTOTOXIC LYMPHOCYTES KILL THEIR TARGETS, Current opinion in immunology, 10(5), 1998, pp. 581-587
Citations number
54
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
10
Issue
5
Year of publication
1998
Pages
581 - 587
Database
ISI
SICI code
0952-7915(1998)10:5<581:HDCLKT>2.0.ZU;2-M
Abstract
CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activa ted killer cells depend primarily on the perforin/granzyme system to k ill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrat es.