BOMBESIN REDUCES FOOD-INTAKE AFTER A PRELOAD IN MAN BY A CHOLECYSTOKININ INDEPENDENT MECHANISM

1. A double-blind study was undertaken to determine whether the infusi on of bombesin inhibits the intake of a carbohydrate-rich meal, consum ed 15 min after a 300 ml banana shake, in nine lean healthy subjects a nd whether the possible inhibition of food intake by bombesin is media ted by cholecystokinin. 2. The amount of food eaten during infusion of bombesin (267+/-60 g) and bombesin combined with the cholecystokinin- receptor antagonist loxiglumide (269+/-39 g) was slightly (P=0.09) les s than during saline infusion (384+/-40 g). In addition, preprandial f eelings of hunger were significantly less during infusion of both bomb esin and bombesin combined with loxiglumide. 3. In conclusion, infusio n of bombesin tends to inhibit the intake of a carbohydrate-rich meal after a preload by a cholecystokinin-independent mechanism.