Results from a series of naming experiments demonstrated that major le
xical categories of simple sentences can provide sources of constraint
on the interpretation of ambiguous words (homonyms). Manipulation of
verb (Experiment 1) or subject noun (Experiment 2) specificity produce
d contexts that were empirically rated as being strongly biased or amb
iguous. Priming was demonstrated for target words related to both sens
es of a homonym following ambiguous sentences, but only contextually a
ppropriate target words were primed following strongly biased dominant
or subordinate sentences. Experiment 3 showed an increase in the magn
itude of priming when multiple constraints on activation converged. Ex
periments 4 and 5 eliminated combinatorial intralexical priming as an
alternative explanation. Instead, it was demonstrated that each constr
aint was influential only insofar as it contributed to the overall sem
antic representation of the sentence. When the multiple sources of con
straint were retained but the sentence-level representation was change
d (Experiment 4) or eliminated (Experiment 5), the results of Experime
nts 1, 2, and 3 and were not replicated. Experiment 6 examined the iss
ue of homonym exposure duration by using an 80-msec stimulus onset asy
nchrony. The results replicated the previous experiments. The overall
evidence indicates that a sentence context can be made strongly and im
mediately constraining by the inclusion of specific fillers for salien
t lexical categories. The results are discussed within a constraint-ba
sed, context-sensitive model of lexical ambiguity resolution.