COAGULATION AND FIBRINOLYSIS PARAMETERS IN NORMAL-PREGNANCY AND IN GESTATIONAL DIABETES

The changes in coagulation and fibrinolysis parameters during pregnanc y, delivery and 3 days after delivery were evaluated in normotensive a nd gestational diabetes pregnant women. Normal pregnant women (n = 60) and pregnant women with gestational diabetes (n = 15) formed the stud y population. Coagulation and fibrinolysis parameters were estimated u sing commercial tests. Antithrombin III, thrombin-antithrombin III com plexes, heparin cofactor II, protein C, protein S, tissue plasminogen activator, (t-PA) D-dimer and plasminogen activator inhibitor(PAI-1 an d PAI-2) activities in normal and gestational diabetes pregnancies wer e determined. Thrombin-antithrombin III complexes increased and coagul ation inhibitors decreased in gestational diabetes. Plasminogen activa tor inhibitors remained unchanged and t-PA levels increased in gestati onal diabetes.