DEVELOPMENT OF A NEW CELLULOSE TRIACETATE MEMBRANE WITH A MICROGRADIENT POROUS STRUCTURE FOR HEMODIALYSIS

Dialytic performance and biocompatibility of a newly developed cellulo se triacetate (CTA) membrane with a microgradient porous structure, pr oduced without using polyvinylpyrrolidone (PVP) and liquid paraffin, w ere compared with those of a conventional polysulfone (PS) membrane di alyzer. In vitro and clinical results demonstrated no significant diff erence in the dialytic performance and biocompatibility of the two dia lyzers, but the CTA dialyzer lost less albumin during dialysis than th e PS. These results suggest that a CTA membrane dialyzer with a porous microgradient structure attained comparable performance and biocompat ibility to PS, and the risk of albumin loss was suppressed by the new CTA membrane.