M. Alquist et al., FIRST CLINICAL-EXPERIENCE WITH A NEW CONCENTRATE SYSTEM FOR DIALYSIS WITH DRY SODIUM-CHLORIDE, ASAIO journal, 44(5), 1998, pp. 592-595
Clinical investigation of a new concentrate system for preparing the a
cid concentrate in bicarbonate dialysis was performed to evaluate hand
ling, safety aspects, and correct mixing of the final dialysis fluid.
The system is characterized by an acid concentrate prepared from two c
omponents: a cartridge containing 1.1 kg dry sodium chloride and a con
centrate bag with 500 ml of a highly concentrated solution of: electro
lytes (KCl, MgCl2, CaCl2) and acetic acid. The investigation comprised
a total of 142 treatments. The concentrate system was well accepted b
y the clinical staff and considered safe and easy to handle. Marginal
deviations in electrolyte concentration of the dialysis fluid relative
to set values were observed, but were considered to lack biologic or
clinical relevance. The new concentrate system will facilitate the han
dling of dialysis concentrates and provide a convenient means for indi
vidual tailoring of the dialysis fluid composition.