CLONING AND CHARACTERIZATION OF A HUMAN AND MURINE T-CELL ORPHAN G-PROTEIN-COUPLED RECEPTOR SIMILAR TO THE GROWTH-HORMONE SECRETAGOGUE AND NEUROTENSIN RECEPTORS

Growth hormone secretagogues (GHS) are a group of synthetic peptide an d nonpeptide molecules that potently stimulate the release of GH from the anterior pituitary gland through the activation of a novel G-prote in-coupled receptor (GPC-R), the GHS-R. In our search for GHS-R family members, we recently described the cloning of two related GPC-Rs, GPR 38 and 39. In the present report, we detail the isolation of a new GPC -R (FM-3) from human and mouse with moderate sequence identity to both the GHS-R and neurotensin-rt. FM-3 is expressed in a diverse set of t issues. (C) 1998 Academic Press.