A chiral stationary phase with a silicone backbone and substituted sid
e chains of (S)-N-1-(1-naphthyl)-4-propyloxybenzamide substitution has
been introduced for open tubular column GC and SFC. The stationary ph
ase has a broad temperature working range 20-280 degrees C), and provi
des highly efficient columns (> 3000 plates/meter). One of the key int
eractions for selectivity is the pi-pi interaction, but the stationary
phase can also be used to separate enantiomers without pi electrons.
The phase can be used to separate a broad range of compounds, which is
demonstrated by the separation of enantiomeric compounds having aroma
tic rings, amino acid and terpenic alcohol groups. This stationary pha
se expands the use of Pirkle phases into the field of open tubular col
umn chromatography.