GRANULOCYTE-COLONY-STIMULATING FACTOR ADMINISTERED AS A SINGLE INTRAPERITONEAL INJECTION MODIFIES THE LETHAL DOSE(95 30) IN IRRADIATED B6D2F1 MICE/

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growt h factor that stimulates the proliferation of progenitor myeloid cells . We have previously demonstrated that recombinant human G-CSF (rhG-CS F) significantly improves survival of lethally irradiated B6D2F1 mice when administered as a single intraperitoneal dose of 1 mg/kg 2 hours after a lethal dose (LD)(95/30) irradiation. In our model, rhG-CSF is also able to modify the LD95/30 in irradiated animals and 1.1 has been found to be the dose modification factor (the ratio of LD95/30 for mi ce treated with rhG-CSF to that for control animals).