Rr. Gaiser et al., COMPARISON OF 3 DIFFERENT DOSES OF INTRATHECAL FENTANYL AND SUFENTANIL FOR LABOR ANALGESIA, Journal of clinical anesthesia, 10(6), 1998, pp. 488-493
Study Objective: To compare the duration of analgesia and incidence of
side effects of three doses of intrathecal fentanyl (25 mu g, 37.5 mu
g, 50 mu g) with three doses of intrathecal sufentanil (5 mu g, 10 mu
g, 15 mu g). Design: Randomized, double-blind study. Setting: Labor s
uite of the Hospital of the University of Pennsylvania Patients: 60 AS
A Physical status I and II parturients in active labor who requested a
nalgesia. Interventions: Patients received one of the six doses of opi
oid diluted with normal saline to achieve a volume of 1.5 ml intrathec
ally. Measurements and Main Results: Duration of analgesia, contractio
n pain, degree of pruritus maternal blood pressure, maternal heart rat
e, fetal heart rate, Apgar scores, and neurologic and adaptive capacit
y scores were measured. There was no statistical difference among the
doses of fentanyl in duration of analgesia. In addition, there was no
statistical difference among the doses of sufentanil. The durations of
analgesia for all doses of sufentanil were statistically longer than
that for all doses of fentanyl. There was no difference among all the
groups for maximal pruritus score. The duration of pruritus did not di
ffer among doses of fentanyl or sufentanil; the duration of pruritus w
as significantly longer for sufentanil. All groups had a decrease in b
lood pressure. There was no difference among the groups in regard to t
he effect on the systolic or diastolic blood pressure. Conclusions: In
trathecal sufentanil produced analgesia of longer duration than fentan
yl for all doses studied The duration of pruritus with sufentanil was
also longer. (C) 1998 by Elsevier Science Inc.