Clonidine has both analgesic and sedative actions, and it has been use
d in a variety of settings as an analgesic, as a sedative, or both. We
administered oral clonidine with intravenous Ketamine to a burn patie
nt to control severe pain. Clonidine produced good analgesia and sedat
ion. In addition, clonidine counterbalanced the sympathetic stimulatio
n of ketamine by virtue of its action in reducing sympathetic outflow.
The combination of these two drugs may be useful for burn patients wi
th hypertension or myocardial ischemia. (C) 1998 by Elsevier Science I
nc.