IMEDEEN(R) IN THE TREATMENT OF PHOTOAGED SKIN - AN EFFICACY AND SAFETY TRIAL OVER 12 MONTHS

Background UV-exposure induces photoaging of the skin. Objective Testi ng the efficacy and safety of oral imedeen(R) in photoaged skin. Metho ds Three month placebo-controlled randomized study of 144 subjects and 9-month-uncontrolled continuation. Efficacy measurements included cli nical evaluation, self-evaluation, photograph evaluation, as well as u ltrasound, transepidermal water loss and replica measurements. Results After 3 months, no significant effects were detected. One years treat ment gave significant improvement compared with baseline in investigat or's evaluation of fine lines and overall photoaging, in photograph ev aluation of fine lines, overall photoaging, telangiectasia and hyperpi gmentation, in self-evaluation of skin condition, density measurements by ultrasound, trans-epidermal water loss and skin smoothness from an alysis of skin replica. No serious side-effects related to treatment w ere reported. Conclusion Imedeen(R) appears effective and safe for tre atment of photoaged skin. (C) 1998 Elsevier Science B.V. All rights re served.