CUTANEOUS ANGIOMYOLIPOMA - REPORT OF 2 CASES WITH EMPHASIS ON HMB-45 UTILITY

Background Angiomyolipomas are tumors composed of adipose tissue, bloo d vessels and smooth muscle. Although renal angiomyolipomas are well k nown, cutaneous tumors have been described only recently. HMB-45 react ivity, reported for renal angiomyolipomas, has been suggested as a use ful tool in differential diagnosis. Objective Two cases of cutaneous a ngiomyolipoma are described and investigated for HMB-45 reactivity. Me thods Conventional histochemical and immunohistochemical methods were used. Results Immunohistochemical analysis showed no reactivity for HM B-45 antibody.Conclusion We conclude that, unlike renal angiomyolipoma s, HMB-45 reactivity is not helpful in differentiating cutaneous angio myolipomas. (C) 1998 Elsevier Science B.V. All rights reserved.